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Contact Info

William H. Sanders
Interim Department Head
ECE ILLINOIS
1406 W. Green St.
Urbana, IL 61801-2918
Ph: (217) 333-2300
Fax: (217) 244-7075
whs@illinois.edu

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Rohit Bhargava

Electrical and Computer Engineering
Rohit  Bhargava
Rohit Bhargava
Professor
  • Bioengineering
4265 Beckman Institute MC 251
405 N. Mathews
Urbana Illinois 61801
(217) 265-6596

Affiliation

  • Bioengineering

Primary Research Area

  • Biomedical Imaging

Education

Ph.D. (Macromolecular Science and Engineering), Case Western Reserve University, Cleveland, Ohio, 2000.

Academic Positions

  • Co-Leader, HABITS--Health: Attitudes, Biology, Information Technology, Society Initiative, Beckman Institute, 2010-present
  • Affiliate Faculty, Computational Science and Engineering Program, University of Illinois at Urbana-Champaign, Urbana, IL, 2006-present
  • Faculty, Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 2008- present
  • Research Affiliate, Mills Breast Cancer Institute, Carle Foundation Hospital, 2010-present
  • Affiliate Faculty, Department of Mechanical Science & Engineering, Electrical & Computer Engineering, Chemical & Biomolecular Engineering,University of Illinois at Urbana-Champaign, Urbana, IL, 2011-present
  • Associate Director and member, University of Illinois Cancer Center, University of Illinois at Urbana-Champaign, Urbana, IL, 2011-present
  • Full-time faculty, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 2005-present
  • Assistant Professor, Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, 2005-2011
  • Associate Professor, Department of Bioengineering,University of Illinois at Urbana-Champaign, Urbana, IL, 2011-2012
  • Professor and Bliss Faculty Scholar, University of Illinois at Urbana-Champaign, Urbana, IL., 2012-present

For more information

Other Professional Employment

  • Research Assistant, NSF Center for Advanced Liquid Crystalline Optical Materials, Case Western Reserve University, Cleveland, OH, October 1996-February 2000.
  • Research Fellow, Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, MD, March 2000-August 2005.

Major Consulting Activities

Johnson & Johnson, Spring House, PA

Undergraduate Research Opportunities

Undergraduate researchers in Prof. Bhargava's group help develop methods for diagnosing and grading cancer, in developing nanoparticle probes for optical imaging, in tissue engineering and in developing new computer software.

Research Interests

  • Biomedical image processing
  • Polymer dynamics
  • Cancer pathology
  • Fourier transform infrared spectroscopy
  • Chemical Imaging

Books Edited or Co-Edited (Original Editions)

R. Bhargava and I. W. Levin, eds., Spectrochemical Analyses Using Multichannel Infrared Detectors, Blackwell Publishing, UK, 2005

Chapters in Books

  • R. Bhargava and I. W. Levin, "Recent Development in Fourier Transform Infrared (FTIR) Microspectroscopic Methods for Biomedical Analyses: From Single Point Detection to Two-Dimensional Imaging," Biomedical Photonics Handbook, CRC Press, Vo-Dinh Tran, ed., 2002.
  • R. Bhargava and I. W. Levin, "Mid-infrared Spectroscopic Imaging with Multichannel Detectors" in Spectrochemical Analyses using Multichannel Infrared Detectors, Blackwell Publishing, R. Bhargava and I. W. Levin, eds., 2005.
  • R. Bhargava, M. D. Schaeberle, and I. W. Levin, "Mid-infrared and Raman Spectroscopic Imaging" in Vibrational Spectroscopy of Biological and Polymeric Materials, Marcel Dekker, V. G. Gregariou and M. Braiman, eds., 2005.
  • R. Bhargava, I.W. Levin, "Prostate Cancer Diagnosis by FTIR Imaging," M. Diem, P.R. Griffiths and J. Chalmers, eds., 2009.
  • A.K. Kodali, R. Bhargava "Nanostructured Probes to Enhance Optical and Vibrational Spectroscopic Imaging for Biomedical Applications", Y.Y. Fu and A. Narlikar, eds. 2010.
  • R.K. Reddy, R. Bhargava “Chemometric methods for biomedical vibrational spectroscopy and imaging”, P. Matousek and M.D. Morris, eds. 2010.
  • F.N. Pounder, R. Bhargava “Breast cancer pathology by infrared spectroscopy”, G. Srinivasan, ed, McGraw-Hill (2010 – anticipated)
  • M.J. Walsh, R. Bhargava “Infrared spectroscopic imaging: an integrative approach to pathology” G. Popescu, ed. “Nanobiophotonics” McGraw-Hill (2010)
  • K. Yeh, R.K. Reddy, R. Bhargava “Fourier transform infrared spectroscopic imaging” Emerging Imaging Technologies for Medicine, M. Anastasio and P. La Riviere, eds, Taylor Francis/CRC Press 2012

Selected Articles in Journals

  • • R. Bhargava, S.Q. Wang, J.L. Koenig “FT-IR imaging of the interface in multicomponent systems using optical effects induced by differences in refractive index” Appl. Spectrosc. 52, 323-328 (1998) [Accelerated Publication]
  • • U.S. Agarwal, R. Bhargava, R.A. Mashelkar “Brownian dynamics simulation of a polymer molecule in solution under elongational flow” J. Chem. Phys. 108, 1610-1616 (1998)
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “FTIR imaging studies of a new two-step process to produce polymer dispersed liquid crystals” Macromolecules 32, 2748-2760 (1999)
  • • R. Bhargava, T. Ribar, J.L. Koenig “Towards faster FT-IR imaging by reducing noise” Appl. Spectrosc. 53, 1313-1322 (1999)
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “Studying polymer-dispersed liquid-crystal formation by FTIR spectroscopy. 1. Monitoring curing reactions”, Macromolecules 32, 8982-8988 (1999)
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “Studying polymer-dispersed liquid-crystal formation by FTIR spectroscopy. 2. Phase separation and ordering”, Macromolecules 32, 8989-8995 (1999)
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “Route to higher fidelity FT-IR imaging” Appl. Spectrosc. 54, 486-495 (2000)
  • • R. Bhargava, B.G. Wall, J.L. Koenig “Comparison of the FT-IR mapping and imaging techniques applied to polymeric systems” Appl. Spectrosc. 54, 470-479 (2000)
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “Processing FTIR Imaging Data for Morphology Visualization” Appl. Spectrosc. 54, 1690-1706 (2000)
  • • T. Ribar, R. Bhargava, J.L. Koenig “Examining Polymer Dissolution by FTIR Imaging: 1. Good Solvents” Macromolecules 33, 8842-8849 (2000)
  • • R. Bhargava, D.C. Fernandez, M.D. Schaeberle, I.W. Levin “Effect of Focal Plane Array Cold Shield Aperture Size on Fourier Transform Infrared Imaging Microspectrometer Performance”, Appl. Spectrosc. 54, 1743-1750 (2000)
  • • J.L. Koenig, S.Q. Wang, R. Bhargava “FTIR Images: A picture is worth a thousand spectra” Anal. Chem. 73, 351A-391A (2001) [Cover Feature Article]
  • • R. Bhargava, D.C. Fernandez, M.D. Schaeberle, I.W. Levin “Towards Faster FTIR Imaging” Appl. Spectrosc. 55, 1079-1084 (2001)
  • • T. Ribar, R. Bhargava, J.L. Koenig “Examining Polymer Dissolution by FTIR Imaging: 2. Good-Poor Solvent Mixtures” Macromolecules 34, 8340-8346 (2001)
  • • R. Bhargava, I.W. Levin “FTIR imaging: Theory and Practice” Anal. Chem. 73, 5157-5167 (2001)
  • • R. Bhargava, D.C. Fernandez, M.D. Schaeberle, I.W. Levin “Gain Ranging for FTIR Imaging” Appl. Spectrosc. 54, 1580-1589 (2001)
  • • R. Bhargava, I.W. Levin “Fourier Transform Infrared Spectroscopic Imaging of Biological Tissue” Trends Appl. Spectrosc. 3, 57-67 (2001)
  • • R. Bhargava, I.W. Levin “A Critical Analysis of Time Averaging and Multiplexing in Fourier Transform Infrared Spectroscopic Imaging” Anal. Chem. 74, 1429-1435 (2002)
  • • S.W. Huffman, R. Bhargava, I.W. Levin “A Generalized Implementation of Rapid-Scan Fourier Transform Infrared Spectroscopic Imaging” Appl. Spectrosc. 56, 965-969 (2002) [Accelerated Publication]
  • • R. Bhargava, I.W. Levin “Non-invasive Imaging of Molecular Dynamics in Heterogeneous Materials” Macromolecules 36, 92-96 (2003) [Featured in Anal. Chem. News Section, July 2003]
  • • R. Bhargava, I.W. Levin “Time Resolved Fourier Transform Infrared Spectroscopic Imaging” Appl. Spectrosc. 57, 357-366 (2003) [Accelerated Publication]
  • • R. Bhargava, S.Q. Wang, J.L. Koenig “FTIR Microspectroscopy of Polymeric Systems” Adv. Polym. Sci. 163, 137-191 (2003)
  • • R. Bhargava, I.W. Levin “Probing the Structure and Dynamics of Macromolecular Composites by Infrared Spectroscopy and Imaging” Vib. Spectrosc. 34, 13-24 (2004) [Invited Special Issue: Prominent Young Vibrational Spectroscopists]
  • • R. Bhargava, I.W. Levin “Enhanced Time-resolved Fourier Transform Infrared Spectroscopic Imaging for Reversible Dynamics” J. Phys. Chem. A 108, 3896-3901 (2004)
  • • R. Bhargava, I.W. Levin “Application of Gram-Schmidt Orthogonalization to Spectroscopic Imaging” Appl. Spectrosc. 58, 995-1000 (2004)
  • • I.W. Levin, R. Bhargava “Fourier Transform Infrared Vibrational Spectroscopic Imaging: Integration of Microscopy and Molecular Recognition” Annu. Rev. Phys. Chem., 56, 429-474 (2005)
  • • D.C. Fernandez,* R. Bhargava,* S.M. Hewitt, I.W. Levin “Infrared Spectroscopic Imaging For Histopathologic Recognition” Nature Biotechnol., 23, 469-474 (2005) [*equal first authors]
  • • R. Bhargava, D.C. Fernandez, S.M. Hewitt, I.W. Levin “High throughput assessment of cells and tissues: Bayesian classification of spectral metrics from infrared vibrational spectroscopic imaging data” Biochim Biophys Acta. 1758, 830-845 (2006)
  • • R. Bhargava, S.M. Hewitt, I.W. Levin “Re:Unrealistic Expectations for IR Microspectroscopic Imaging” Nature Biotechnol., 25, 31-33 (2007)
  • • G. Srinivasan, R. Bhargava “Fourier transform infrared spectroscopic imaging: the emerging evolution from a microscopy tool to a cancer imaging modality” Spectroscopy, 22, 40-51 (2007)
  • • R. Bhargava “Practical FTIR chemical imaging for cancer pathology” Anal. Bioanal. Chem., 389, 1155-1169 (2007)
  • • K. Park, J. Lee, R. Bhargava, W.P. King “Femtogram-Level Sampling for Spectroscopic Analysis Using Functional Self-Cleaning Scanning Probe Tips” Anal. Chem. 80, 3221 -3228 (2008)
  • • X. Llora, A.Priya, R. Bhargava “Observer-Invariant Histopathology using Genetics-Based Machine Learning” Nat. Computing, 8, 101-120 (2009)
  • • R. Bhargava, R.S. Perlman, D.C. Fernandez, I.W. Levin, E.G. Bartick “Non-invasive detection of superimposed latent fingerprints and inter-ridge trace evidence by infrared spectroscopic imaging” Anal Bioanal. Chem. 394, 2069–2075 (2009)
  • • B.J. Davis, P.S. Carney, R. Bhargava “Theory of mid-infrared absorption microspectroscopy. I. Homogeneous samples” Anal. Chem., 82, 3474–3486 (2010) DOI: 10.1021/ac902067p
  • • B.J. Davis, P.S. Carney, R. Bhargava “Theory of mid-infrared absorption microspectroscopy. II. Heterogeneous samples” Anal. Chem., 82, 3487–3499 (2010) DOI: 10.1021/ac902068e
  • • R. Kong, R.K. Reddy, R. Bhargava “Characterization of Tumor Progression in Engineered Tissue using Infrared Spectroscopic Imaging” Analyst 135, 1569-1578 (2010) DOI: 10.1039/c0an00112k
  • • M.V. Schulmerich, A.K. Kodali, R.K. Reddy, L.J. Elgass, R. Bhargava “Dark field Raman Microscopy” Anal. Chem., 82, 6273–6280 (2010) DOI: 10.1021/ac1014194
  • • A.K. Kodali, M.V. Schulmerich, J. Ip, G. Yen, B.T. Cunningham, R. Bhargava “Narrowband Mid-infrared reflectance filters using guided mode resonance” Anal. Chem., 82, 5697–5706 (2010) DOI: 10.1021/ac1007128
  • • A.K. Kodali, X. Llora, R. Bhargava “Optimally tailored Raman spectroscopic probes for ultrasensitive and highly multiplexed assays” Proc. Natl. Acad. Sci., 107, 13620-13625 (2010) DOI: 10.1073/pnas.1003926107
  • • R.K. Reddy, R. Bhargava “Automated noise reduction for accurate classification of tissue from low signal-to-noise ratio imaging data” Analyst, 135, 2818-2825 (2010) DOI: 10.1039/C0AN00350F
  • • A.K. Kodali, M.V. Schulmerich, R. Palekar, X. Llora, R. Bhargava “Optimized Nanospherical Layered Alternating Metal-dielectric Probes for Optical Sensing” Opt. Exp., 18, 23302-23313 (2010)
  • • J. G. Moreno-Torres, X. Llora, D.E. Goldberg, R. Bhargava “On the homogenization of data from two laboratories using genetic programming” Lec. Notes Comp. Sci., 6471/2010, 185-197 (2010), DOI: 10.1007/978-3-642-17508-4_12.
  • • B. Kwon, C. Wang, K. Park, R. Bhargava, W.P. King “Themomechanical Sensitivity of Microcantilevers in the Mid-infrared Spectral Region”, Nano Micro Thermophys Eng, 15, 16-28 (2011)
  • • B.J. Davis, P.S. Carney, R. Bhargava “Infrared Microspectroscopy of Intact Fibers” Anal. Chem. 83, 525–532. (2011)
  • • J.T. Kwak, S.M. Hewitt, S. Sinha, R. Bhargava “Multimodal microscopy for automated histologic analysis of prostate cancer” BMC Cancer 11, 62- (2011) [Designated “Highly Accessed”]
  • • J. G. Moreno-Torres, X. Llora, D.E. Goldberg, R. Bhargava “Repairing Fractures between Data using Genetic Programming-based Feature Extraction: A Case Study in Cancer Diagnosis” Information Sciences, In press (2011).
  • • M.J. Nasse, M.J. Walsh, E.C. Mattson, R. Reininger, A. Kajdacsy-Balla,V. Macias, R. Bhargava,* C.J. Hirschmugl* “High-resolution Fourier transform infrared chemical imaging with multiple synchrotron beams” Nat. Methods, 8, 413-416 (2011) DOI:10.1038/NMETH.1585 [*Joint corresponding authors]
  • • R. Kong, R. Bhargava “Characterization of Porcine Skin as a Model for Human Transdermal Diffusion” Analyst 136, 2359 - 2366 (2011) DOI: 10.1039/C1AN15111H
  • • S.E. Holton, M.J. Walsh, R. Bhargava “Localizing subcellular biochemical transformations in cancer-activated fibroblasts using high-resolution infrared spectroscopic imaging” Analyst 136, 2953-2958 (2011) DOI: 10.1039/c1an15112f
  • • J. Yao, A. Le, M.V. Schulmerich, J. Maria, T. Lee, S.K. Gray, R. Bhargava, J.A. Rogers, R.G. Nuzzo “Soft Embossing of Nanoscale Optical and Plasmonic Structures in Glass” ACS Nano, 5, 5763–5774 (2011) - DOI 10.1021/nn201464t.
  • • S. E. Holton, M.J. Walsh, A. Kajdacsy-Balla, R. Bhargava “Label-free characterization of cancer-activated fibroblasts in cell culture and clinical tissues using infrared spectroscopic imaging” Biophys. J. 101, 1513-1521 (2011) – DOI: 10.1016/j.bpj.2011.07.055
  • • A.K. Kodali, R. Bhargava “Effect of non-specificity in shape, size, and dielectric properties on electromagnetic extinction and optical field enhancement from spherical nanolayered metal-dielectric particles" Theor Chem Acc 130, 991-1000 (2011) [Invited] - DOI: 10.1007/s00214-011-1038-1
  • • D. Chanda, K. Shigeta, T. Truong, E. Lui, A. Mihi, M.V. Schulmerich, P.V. Braun, R. Bhargava, J.A. Rogers “Cavity-coupled quasi-three dimensional plasmonic crystals” Nat. Commun. 2, 479 (2011) DOI: 10.1038/ncomms1487
  • • J. Liu, M.V. Schulmerich, R. Bhargava, B.T. Cunningham “Optimally designed narrowband mid-infrared guided-mode resonance reflectance filters for mid-infrared optical spectroscopy” Opt. Exp. 19, 24182-24197 (2011). DOI: 10.1364/OE.19.024182
  • • D.M. Mahr, R. Bhargava, M.F. Insana “Multimodal image simulations using in-silico breast phantoms” IEEE Trans. Med. Imaging 31, 689 - 697 (2012). DOI: 10.1109/TMI.2011.2175401
  • B. Kwon, M. Rosenberger, R. Bhargava, D.G. Cahill, W.P. King “Dynamic Thermomechanical Response of Bimaterial Microcantilevers to Periodic Heating by Infrared Radiation” Rev. Sci. Instr. 83, 015003 (2012) DOI: 10.1063/1.3680107
  • J.T. Kwak, R.K. Reddy, S. Sinha, R. Bhargava “An analysis of the sources of variance in Fourier transform infrared spectroscopic imaging of tissues” Anal. Chem. 84, 1063-1069 (2012) DOI: 10.1021/ac2026496
  • B. Kwon, M.V. Schulmerich, S. Holton, R. Bhargava, W.P. King “Infrared microspectroscopy combined with conventional atomic force microscopy” Ultramicroscopy 116, 56-61. (2012)
  • M.J Walsh, S.E. Holton, A. Kajdacsy-Balla, R. Bhargava “Attenuated Total Reflectance Fourier Transform Infrared Spectroscopic Imaging for Comprehensive Breast Tissue Histopathology” Vib. Spectrosc. 60, 23-28 (2012) DOI: 10.1016/j.vibspec.2012.01.010
  • M.J. Walsh, R.K. Reddy, R. Bhargava “Label-free Biomedical Imaging with Mid-Infrared Microspectroscopy” IEEE J Sel Top Quant 18,1502 - 1513 (2012) [invited] DOI: 10.1109/JSTQE.2011.2182635
  • N. Lv, S.E. Mylon, R. Kong, R. Bhargava, J.L. Zilles, T.H. Nguyen “Interactions between dissolved natural organic matter and adsorbed DNA and their effect on natural transformation of Azotobacter vinelandii” Sci. Total Environ.. 426, 430-435 (2012)
  • S.A. Odom, T.P. Tyler, M.M. Caruso, J. Ritchey, M.V. Schulmerich, S.J. Robinson, R. Bhargava, N.R. Sottos, S.R. White, M.C. Hersam, J.S. Moore “Autonomic Restoration of Electrical Conductivity Using Polymer-Stabilized Carbon Nanotube and Graphene Microcapsules” Appl. Phys. Lett. 101, 043106 (2012)
  • R.K. Reddy, M.J. Walsh, M.V. Schulmerich, P.S. Carney, R. Bhargava “High-definition infrared spectroscopic imaging” Appl. Spectrosc. In press (2012)
  • • M.V. Schulmerich, M.J Walsh, M. Gelber, R. Kong, M. Kole, S. Harrison, J. McKinney, D. Thompson, L. Kull, R. Bhargava “Compositional analysis of soybean seed by Transmission Raman spectroscopy” J. Agric. Food. Chem. (2012)
  • R. Ambekar, T. Lau, M.J. Walsh, R. Bhargava, K. Toussaint “Quantifying collagen transformations in breast biopsies using second-harmonic generation imaging” Biomed. Opt. Exp. 3, 2021-2035 (2012)
  • R. Bhargava “Infrared Spectroscopic Imaging: The next generation” Appl. Spectrosc. In press (2012) [Invited Focal Point Article]
  • M. Kole, M.V. Schulmerich, M. Gelber, R. Bhargava “Discrete frequency infrared microspectroscopy and imaging with a tunable quantum cascade laser” Anal. Chem. In press (2012) DOI: dx.doi.org/10.1021/ac302513f

Teaching Honors

  • AE3 Scholar, Academy for Excellence in Engineering Education (2005)
  • Incomplete Lists of Teachers Ranked as Excellent, 8 times (2006-present)
  • Accenture Outstanding Faculty Award for Undergraduate Advising (2007, 2009)
  • Everitt Award for Teaching Excellence (2009)
  • Teaching Academy Faculty Fellow in Engineering (2010)
  • Teaching Academy Faculty Fellow in Engineering (2011)
  • Rose Award for Teaching Excellence (2012)

Research Honors

  • William F. Meggers Award, Society for Applied Spectroscopy (1999)
  • National Science Talent Search Scholar, NCERT, India (1989-1996)
  • The Undergraduate Research Award, IIT-D (1994)
  • The Roll of Honour for Outstanding Cumulative Contribution as an Undergraduate (1996)
  • Samuel H. Maron Award, Case Western Reserve University (1998)
  • Sigma Pi Epsilon Honor Society, Society of Plastic Engineers (2000)
  • Case Alumni Award for Best Graduate Spectroscopist (2000)
  • William F. Kirkbright Bursary Award, Association of British Spectroscopists (2001)
  • William F. Meggers Award, Society for Applied Spectroscopy (2002)
  • Best Manuscript, Prominent Young Vibrational Spectroscopists' Issue of Vibrational Spectroscopy (2004)
  • Faculty Fellow, National Center for Supercomputing Applications (2006)
  • Bronze Medal, Human-Competitive Competition, GECCO07 (2007)
  • DoD Young Investigator, Prostate Cancer Research program (2007)
  • Fellow, Center for Advanced Study (2010)
  • Xerox Award for Faculty Research (2011)
  • Campus award for outstanding promotion and tenure dossier (2011)
  • FACSS Innovation Award (2012)

Public Service Honors

  • Ramachandra Rao Dasari Lecture, Indian Institute of Technology, Kanpur (2008)
  • Society for Applied Spectroscopy National Tour Speaker (2008)